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KMID : 1377020160130030297
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Tissue Engineering and Regenerative Medicine
2016 Volume.13 No. 3 p.297 ~ p.303
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Local injection of granulocyte-colony stimulating factor accelerates wound healing in a rat excisional wound model
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Shen Guang-Yin
Park In-Hwa
Song Yi-Sun
Joo Hyun-Woo
Lee Yong-Gu
Shin Jeong-Hun
Kim Kyung-Soo
Kim Hyuck
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Abstract
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A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes.
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KEYWORD
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Granulocyte-colony stimulating factor, Wound healing, Local injection
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